Endocrine Abstracts

Introduction: Isolated eosinophilic pancreatitis is very rare disease and usually occurs either as hyperoesinophylia syndrome or as part of eosinophilic gastroenteritis.Case report: A 55-year-old man presented to his general practitioner (GP) with a 3 week history of flu-like symptoms, pruritis, weight loss and diarrhoea. Initial investigations showed eosinophilia (32.2 ×109/l) and a normal random glucose.He was see...

We report a rare case of propylthiouracil (PTU) induced ANCA-associated-vasculitis (AAV). This young lady with recurrent thyrotoxicosis and positive Thyroid peroxidase and TSH receptor antibodies since 2004 was treated with Carbimazole but was changed to PTU 100 mg daily during pregnancy in 2012.She was admitted to our hospital in January 2015 with sore throat, feeling unwell and neutropenia 1.2 (normal range (NR): 1.6–7.5) 10×9/l. Thyroid func...

Aims: To assess the prevalence, investigations and management of hyponatraemia in hospital inpatients (previously deemed inadequate) over a 2-week period (1–15 May 2013) and compare with data collected in 2011, following the introduction of updated clinical guidelines in our trust.Methods: Hospital notes and electronic records of all patients with a sodium level of <130 mmol/l were analysed.Results: 43/255 (17%) patients h...

Introduction: LH resistance is very rare and there are only a few case reports in the literature. We describe a patient who presented to us with secondary amenorrhea and very high isolated LH levels who subsequently had a successful pregnancy with IVF.Case report: A 16 year old girl was referred to us to investigate the cause of her oligomenhorrea. She had attained menarche at the age of 13 and had only 5 periods in 3 years. She had no symptoms/signs of ...

A 58-year old female with long standing type 1 diabetes and treated hypothyroidism presented to casualty with a 1-day history of vomiting and breathlessness. Clinically she was dehydrated with a depressed conscious level (GCS=12). Initial investigations confirmed diabetic ketoacidosis (pH=6.8, bicarbonate=4.7 mmol/l, urinary ketones=4+, blood glucose=54.6 mmol/l) and acute renal failure, likely to be secondary to pneumonia as there was consolidation on her CXR and a raised WCC...

Some patients with Cushing’s have only periodic hypercortisolism, known as cyclical Cushing’s, becoming eucortisolaemic or even transiently subnormal between periods of hypercortisolaemia. We report two cases and discuss the management.A 23-year-old lady presented in March 2007 with Cushingoid features. Initial urinary free cortisol was raised at 594 nmol/l. A midnight cortisol of 568 nmol/l and post-48 h low dose dexamethasone cortisol of 351 ...

Background: Following the advent of thyroid function screening and highly sensitive TSH assay subclinical hyperthyroidism (SCHT) is becoming increasingly common. No audit addressed the treatment outcome of this group of patients.Methods: Prospective analysis of management outcome of patients seen in endocrine clinic over 36 months was carried out. 46 patients who presented with SCHT were included, of whom 41 had confirmed SCHT on repeat testing.<p cl...

Clinical outcome and Implications for training in thyroid surgery in a district general HospitalAuthors: Rajashekhar Rao, Kanagaraj Marimuthu, and Paul ThomasObjective: To assess the volume of work outcome and training opportunity in adistrict general Hospital and compare with the BAES recommendationsMethods: Retrospective study, Patients identified by theatre records, pathology<p c...

The basic mechanisms underlying thyroid growth and proliferation in thyroid cancer are still incompletely characterized. Lithium inhibits GSK3beta and affects via phosphorylation the degradation of free beta-catenin, a potent transcription factor. Hence, using lithium as a model to modulate the wnt/beta-catenin pathway, we investigated its potential activation in-vitro in neoplastic human thyroid cell lines (FTC133, NPA).Our results show that lithium fun...

52 year old lady was referred to the endocrine clinic with h/o lethargy and tiredness. She also had mild tremors. She denied weight loss, palpitations or diarrhoea. Past medical history includes bipolar disorder. She was on Venlafaxine, Carbamazepine, Pregabalin and HRT. GP has done thyroid functions because of the symptoms and results are as below. TSH: 7.15 mIU/l(0.38–5.50), FT4:24.3pmol/l (10.0–18.7) on 05.02.2020 TPO:<10 IU/Ml This was rechecked in a different laborator...